Microglial Self-Recognition STINGs in A-T Neurodegeneration.

 2019 Oct 14. pii: S0166-2236(19)30178-X. doi: 10.1016/j.tins.2019.09.005. [Epub ahead of print]

Microglial Self-Recognition STINGs in A-T Neurodegeneration.

Ferro A1, Sheeler C1, Cvetanovic M2.

Author information

1
Department of Neuroscience, University of Minnesota, 2101 6th Street South East, Minneapolis, MN 55455, USA.
2
Department of Neuroscience, University of Minnesota, 2101 6th Street South East, Minneapolis, MN 55455, USA; Institute for Translational Neuroscience, University of Minnesota, 2101 6th Street South East, Minneapolis, MN 55455, USA. Electronic address: mcvetano@umn.edu.

Abstract

Microglial inflammation is often seen as a secondary event in neurodegeneration. A recent study by Song et al. demonstrates that loss of ataxia telangiectasia mutated (ATM) activates microglia through the cytosolic DNA sensor STING. This highlights the ability of microglia to recognize and respond to self-DNA, with potentially neurotoxic consequences.

Copyright © 2019 Elsevier Ltd. All rights reserved.

KEYWORDS:

ATM; NF-κB; ataxia telangiectasia; microglia

PMID:
 
31623867
 
DOI:
 
10.1016/j.tins.2019.09.005