Elevated serum IL-8 levels in ataxia telangiectasia.

 2010 Apr;156(4):682-4.e1. doi: 10.1016/j.jpeds.2009.12.007. Epub 2010 Feb 20.
McGrath-Morrow SA1, Collaco JM, Crawford TO, Carson KA, Lefton-Greif MA, Zeitlin P, Lederman HM.

Author information

1
Division of Pediatric Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. smorrow@jhmi.edu

Abstract

Serum interleukin (IL)-8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T. In a cross-sectional study, the geometric mean of IL-8 level was significantly higher in the patients with A-T (P <.0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

PMID:
 
20171651
 
DOI:
 
10.1016/j.jpeds.2009.12.007
[Indexed for MEDLINE]