J Cell Biol. 2019 Feb 19. pii: jcb.201901050. doi: 10.1083/jcb.201901050. [Epub ahead of print]
Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics.
Author information
- 1
- Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX kschlacher@mdanderson.org.
Abstract
The ataxia-telangiectasia mutated (ATM) gene regulates DNA damage repair, oxidative stress, and mitochondrial processes. In this issue, Chow et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806197) connects ATM's oxidative stress response functions to the sensing of metabolic ATP energetics distinctively important in high energy-demanding Purkinje brain cells, which could explain the most distinct A-T patient feature, cerebellar ataxia.
© 2019 Schlacher.
- PMID:
- 30782782
- DOI:
- 10.1083/jcb.201901050