2023 Oct-Dec;66(4):886-887.
 doi: 10.4103/ijpm.ijpm_940_22.

Ataxia-telangiectasia and combined hepatocellular-cholangiocarcinoma: A case report

Affiliations 
    • PMID: 38084558
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Abstract

Ataxia-telangiectasia (A-T) is a rare autosomal recessive disease characterized by ataxia, cutaneous and ocular telangiectasia, impaired immunity with susceptibility to sino-pulmonary infections, radiation sensitivity, and cancers particularly of hemato-lymphoid origin. Liver function tests abnormalities and elevated alfa feto-protein have been reported in A-T; however, there is no reported case of combined hepatocellular-cholangiocarcinoma (cHCC-CC) in literature. These tumors should be treated in similar fashion as in general population; however, reduction of chemotherapy dose might be helpful in decreasing chemo-toxicity.

Keywords: Ataxia-telangiectasia; Combined hepatocellular-cholangiocarcinoma; cHCC-CC.